Abstract
ABSTRACTIn this paper the lateral mobility of membrane components as well as the possibility of its measurement are discussed. The development of our own apparatus for fluorescence one-point microphotolysis is characterized. Alsothe results obtained in the course of determination of the lateral coefficient mobility for selected lipids and melittinare discussed. 1. LATERAL MOBILITY IN MEMBRANE AND METHODS OF ITS STUDY Considering the fluid-mosaic model of membrane one may suppose that the individual membrane components (first of all lipids and proteins) can move quite freely in the plain of the membrane. At the same time one may suggest that the flip-flop type trans-membrane diffusion is slower because hydrophylic components of molecules passthrough the hydrophylic central part of the membrane. Such a notion is, of course, quite approximate. It appeared,however, that lipids really diffuse within the membrane almost freely. On the other hand, many of the proteins aredistributed in the membrane ununiformly and the speed of their lateral motion is, as a rule, much less (approximately102_103 times) than that of lipids, not only in model but in cell membranes.This means that there are certain mechanisms in the membrane which influence the membrane components andconstrain their free diffusion. Some of them are as follows:
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