Abstract
When analysis of global and regional left ventricular function is utilized to assess ischemic zone size, it is assumed: (1) a predictable relationship exists between the two; and (2) this relationship is not significantly affected by changes in loading conditions. This study examined the relationship between ischemic zone size and ventricular performance in 11 anesthetized paced dogs subjected to acute coronary occlusion. Cardiac cine-computed tomography was used to quantify regional and global left ventricular function. Ischemic zone size was quantified autoradiographically following left atrial microsphere injection. Both global and regional left ventricular function were strongly influenced by changes in ventricular loading. We conclude: (1) both global and regional left ischemic dysfunction are only modestly correlated with ischemic zone size during acute coronary occlusion; and (2) estimates of ischemic zone size using measurements of ventricular function are highly load-sensitive.© (1994) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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