<title>Computer modeling of light distributions for diverse PDT applicators</title>

Abstract

We developed a Monte Carlo model to estimate the light distribution in tissue. The underlying assumption of the calculation is the knowledge of the microscopic tissue optical parameters. In the simulation we start with a single point illumination in a 3-D multi-layer tissue model. To get the light distribution for extensive irradiation we convolve the `single point solution' with the expanded irradiance profile. The aim of our simulation is the development and design of diverse PDT-applicators for dosimetry reasons and as an inverse method, the calculation of microscopic tissue optical parameters for different tumor samples from ex vivo measurements.