<title>Application of optical coherence tomography for noninvasive blood glucose monitoring during hyperglycemia</title>

Abstract

Approximately 14 million people in the USA and more than 140 million people worldwide suffer from <i>Diabetes Mellitus</i>. The current glucose sensing technique involves a finger puncture several times a day to obtain a droplet of blood for chemical analysis. Recently we proposed to use optical coherence tomography (OCT) for continuous noninvasive blood glucose sensing through skin. In this paper we tested the OCT technique for noninvasive monitoring of blood glucose concentration in lip tissue of New Zealand rabbits and Yucatan micropigs during glucose clamping experiments. Obtained results show good agreement with results obtained in skin studies, good correlation of changes in the OCT signal slope measured at the depth of 250 to 500 &#956;m with changes in blood glucose concentration, and higher stability of the OCT data points than that obtained from skin.