&lt;strong&gt;Periodic Mesoporous Organosilica Functionalized Sulfonic Acids&lt;sub&gt; &lt;/sub&gt;(PMO-ICS-SO&lt;sub&gt;3&lt;/sub&gt;H) as an Efficient and Recyclable NanoCatalyst for the Unsymmetric Hantzsch reaction&lt;/strong&gt;

Mohammad G Dekamin,Amene Yaghoubi

doi:10.3390/ecsoc-20-a012

Abstract

Hybrid mesoporous organosilica was first introduced in 1999, built from bridged organosilane precursors ((ŔO)3Si–R–Si(OŔ)3; R: organic bridging group, Ŕ: methyl or ethyl). Such mesoporous hybrids have been classiﬁed as periodic mesoporous organosilicas (PMOs). In these materials, the bridging organic moieties which are well distributed inside the inorganic pore wall not only increase mechanical and hydrothermal stabilities, but also higher organic loading and greater avoidance of channel blockage can be achieved in comparison with mesoporous silicas functionalized with terminal organic groups. Polyhydroquinolines, as a family of 1,4-dihydropyridine derivatives, are one of the most important groups of nitrogen heterocycles that have attracted extensive interest because of their promising pharmacological and therapeutic activities such as calcium channel blockers, bronchodilating, antiatherosclerotic, antitumor, vasodilating, geroprotective, hepatoprotective, and antidiabetic. The nanocatalyst were characterized by X-ray diffraction, scanning electron microscopy and thermogravimetric analysis.

Highlights

Polyhydroquinolines, as a family of 1,4-dihydropyridine (1,4-DHP) derivatives, are one of the most significant groups of nitrogen heterocycles that have attracted extensive attention due to their promising pharmacological and therapeutic activities such as, antiatherosclerotic, antitumor, calcium channel blockers, vasodilating, bronchodilating, geroprotective, hepatoprotective, and antidiabetic
Considering that most of the atoms of the starting materials are incorporated into the final product, and that water is the byproduct for some multicomponent reactions (MCRs), these reactions became synthetic tools found in a prominent position
MCRs have the advantage of conserving most of the atoms from the building blocks that are present in the product to generate libraries of compounds in an efficient manner [24]

Summary

Introduction

Polyhydroquinolines, as a family of 1,4-dihydropyridine (1,4-DHP) derivatives, are one of the most significant groups of nitrogen heterocycles that have attracted extensive attention due to their promising pharmacological and therapeutic activities such as, antiatherosclerotic, antitumor, calcium channel blockers, vasodilating, bronchodilating, geroprotective, hepatoprotective, and antidiabetic. To show the efficiency of the catalyst for the synthesis of polyhydroquinolines derivatives (6), the reaction of 4-chlorobenzaldehyde (2a, 1 mmol), dimedone (3, 1 mmol), ethyl acetoacetate (4, 1 mmol) and NH4OAc The reaction conditions were optimized with regard to the best catalyst loading, different solvents and temperature for the synthesis of polyhydroquinolines derivatives.

Results

Conclusion