&lt;strong&gt;1,3,5-Tris(2-hydroxyethyl) isocyanurate-f&lt;/strong&gt;&lt;strong&gt;unctionalized graphene oxide: as a novel and efficient nanocatalyst for the one-pot synthesis &lt;/strong&gt;&lt;strong&gt;of 3,4-dihydropyrimidin-2(1&lt;em&gt;H&lt;/em&gt;)-ones&lt;/strong&gt;

Mohammad G Dekamin,Amir Hossein Fattahi,Amene Yaghoubi,Fatemeh Mehdipoor

doi:10.3390/ecsoc-20-a008

Abstract

The preparation, characterization and catalytic application of a novel 1,3,5-Tris(2-hydroxyethyl) isocyanurate-functionalized graphene oxide is described. The catalyst was characterized by nitrogen adsorption-desorption analysis, scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The thermal stability of the material was also determined by thermal gravimetric analysis (TGA). The catalytic application of 1,3,5-Tris(2-hydroxyethyl) isocyanurate-functionalized graphene oxide nanocatalyst was then investigated in the Biginelli condensation of different aldehydes with urea and alkylacetoacetates under solvent-free conditions and at moderate temperature. Moreover, the significant advantages of this procedure are the stability, reactivity and reusability of the catalyst, low loading of the catalyst, avoiding the use of toxic transition metals, short reaction times, high to excellent yields, easy separation and puriﬁcation of the products.

Highlights

In recent years, graphene has become a popular material, attracting attention in the fields of chemistry, physics, and materials science because of its optimal electronic, thermal, and mechanical properties
The catalyst was characterized with some techniques such as infrared (IR) spectroscopy, thermal gravimetric analysis (TGA), powder X-ray diffraction (PXRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM)
The reaction conditions were optimized with regard to the best catalyst loading, different solvents and temperature for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones derivatives

Summary

Introduction

Graphene has become a popular material, attracting attention in the fields of chemistry, physics, and materials science because of its optimal electronic, thermal, and mechanical properties. The reaction conditions were optimized with regard to the best catalyst loading, different solvents and temperature for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones derivatives. It was observed that low yields of the desired product (5a) were obtained in the presence of the catalyst under ultrasonic and ball-milling conditions (Table 1, entries 1 and 2).

Results

Conclusion