&lt;p&gt;[KEYNOTE] Identifying sex differences in colon cancer metabolism (Video)&lt;/p&gt;

Caroline Johnson,Sajid Khan,Nicholas Rattray,Yawei Zhang,Yuping Cai

doi:10.3390/iecm-3-05847

Abstract

Colon cancer is the second most common cancer to affect women worldwide. While women have a 30-40% lower incidence of colon cancer than men, they have a higher likelihood of cancer presentation on the right-side of the colon. This is of high concern because patients with right-sided colon cancer have poorer clinical outcomes than those with left-sided colon cancers. The reasons for this difference in outcome are not known, however, it has been proposed that female hormones influence colonic metabolism, microbiome and affect tumor growth in this region of the colon. We have initially examined the metabolic differences between 210 colon tumor tissues from men and women with left and right-sided colon cancer using untargeted liquid chromatography mass spectrometry-based metabolomics. We show region- and sex-specific differences in tumor tissue metabolism that may influence tumor aggressiveness and patient outcomes. Video from the Keynote Speaker Dr. Caroline H. Johnson can be found as below:

Highlights

Sex chromosomes and steroid sex hormones heavily influence metabolic processes.Energy balance Glucose metabolism Lipid metabolismObesity Diabetes Cancer Cardiovascular DiseaseClegg, D.J., et al Mol
Research on chronic diseases are heavily biased towards men
While women have a 30-40% lower incidence of colon cancer than men, they have a higher likelihood of cancer presentation on the rightside of the colon

Summary

Introduction

Sex chromosomes and steroid sex hormones heavily influence metabolic processes.Energy balance Glucose metabolism Lipid metabolismObesity Diabetes Cancer Cardiovascular DiseaseClegg, D.J., et al Mol. Sex chromosomes and steroid sex hormones heavily influence metabolic processes.

Results

Conclusion