Abstract
Purpose: To formulate and evaluate sustained release microspheres of nateglinide (NTG) for enhanced patient compliance.Methods: Nateglinide microspheres were prepared with varying proportions of biodegradable polymers (olibanum gum and guar gum) by calcium chloride/sodium alginate ionic gelation method. The microspheres were characterized by micromeritic analysis, particle size analysis, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and in vitro drug release studies. Yield and encapsulation efficiency were also evaluated while drug release data were subjected to various kinetic models.Results: Micromeritic analysis showed good flow properties of the microspheres while yield and microsphere size were in the range of 70 to 80 % and 781 to 842 μm, respectively. FTIR and DSC results indicate the absence of drug-polymer interactions while SEM revealed that microspheres were almost spherical shape and porous in nature. Drug release was sustained in simulated intestinal fluid (pH 7.2), extending up to 10 to 12 h with greater release retardation in microspheres containing olibanum gum. The release pattern followed Higuchi kinetics model with non-Fickian diffusion.Conclusion: Suitable microspheres for sustained release of nateglinide can be formulated by ionic gelation method.Keywords: Nateglinide, Microspheres, Micromeritics, Drug release, Ionic gelation, Olibanum gum, Guar gum
Highlights
Oral route is the most convenient, predominant, acceptable and preferable route for solid drug administration
Free flowing white colored nateglinide microspheres were successfully prepared by ionic gelation technique
The particle size of microspheres was in the range of 781 ± 2.08 to 842 ± 1.15 μm, while yield varied from 72 to 78 % for the formulations
Summary
Oral route is the most convenient, predominant, acceptable and preferable route for solid drug administration. Oral drug delivery systems (DDS) are commonly divided into immediate release and modified release systems. Modified DDS are designed for control or target release of the drug, to achieve a desired pharmacokinetic profile, to enhance patient compliance and to minimize adverse drug reactions. Microencapsulation is the application of a thin coating to individual core materials of active substance that have an arbitrary particle size range from 1 - 1000 μm [1]. Microencapsulation can be used to convert the liquids to solids, alter the colloidal and surface properties, provide environmental protection and control drug release characteristics by using the coating materials. Trop J Pharm Res, July 2014; 13(7):1047
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