Abstract
The present study investigated the effects of short-chain fructooligosaccharides (scFOS) feeding on body weight, fat accumulation, glucose homeostasis and lipid profile in cafeteria (CAF) obese rats. Male Wistar rats were divided randomly into two groups: control group (CTL, n = 10), which received a chow diet and water and CAF (n = 20), which received the cafeteria diet, standard chow and soda. After 30 weeks of diet, 10 animals of CAF group received scFOS in the diet (50 g kg -1 of diet) over a period of 50 days, forming the CAF FOS group. Were evaluated the body weight, fat pad as well as, quantity of feces, glucose tolerance, insulin resistance (IR) and serum lipids levels. Animals submitted to the CAF diet displayed obesity, hyperglycemia, glucose intolerance, hyperinsulinemia and IR. The scFOS feeding not altered obesity, glucose intolerance, hyperinsulinemia and IR. CAF rats also presented hypertriglyceridemia and lower levels of HDL-cholesterol. The CAF FOS animals had reduced serum triglycerides (TG) and increased HDL-cholesterol. Thus, the use of scFOS in the diet can be considered as a hypolipidemic agent in the obese state.
Highlights
Obesity is a world-wide epidemic present in the developed and developing countries (PRENTICE, 2006; CABALLERO, 2007)
The cafeteria diet, called the ‘Western diet’, is an experimental diet that is more closely related to the variety of palatable and caloric foods that are prevalent in Western society and associated with the current obesity epidemic
For the first time using this model of obesity, was showed that the addition of short-chain fructooligosaccharides (scFOS) in the diet over a period of 50 days did not alters obesity parameters and glucose homeostasis, improved values of serum lipids levels
Summary
Obesity is a world-wide epidemic present in the developed and developing countries (PRENTICE, 2006; CABALLERO, 2007). The CAF FOS animals had reduced serum triglycerides (TG) and increased HDL- The current study was carried out to determine the effects of scFOS on obesity, glucose homeostasis and the lipid profile in CAF obese rats.
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