&lt;b&gt;Damage caused by exposure to propofol during gestation of mice

Lucimara Aparecida Sensiate,Karla Lorena Guarido,Maria José Salles,Joelle Toni-Ann Venice Freckleton,Ana Clara Cerato Bispo

doi:10.4025/actascihealthsci.v39i2.34203

<b>Damage caused by exposure to propofol during gestation of mice

Lucimara Aparecida Sensiate, Karla Lorena Guarido + Show 3 more

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https://doi.org/10.4025/actascihealthsci.v39i2.34203

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Abstract

Literature shows that surgical procedure could be necessary at any stage of pregnancy and can cause adverse effects on the mother and fetus. One of the most used anesthetics in surgical centers is propofol however; the safety during pregnancy has not been completely established. The objective of this study was to investigate the possible toxic and teratogenic effects on the intrauterine and post-natal development of mice exposed to the dose of 15 mg kg-1 propofol on the caudal vein fifth, tenth and fifteenth day of gestation. A significant reduction in weight gain was observed in female mice who received a 15 mg kg-1 dose of propofol on the fifth gestational day. A higher rate of embryonic loss post implantation and resorption was also observed in this group. In regards to physical development, the anesthetic increased significantly the offspring weight gain, the time in which pinna detachment occurred, and the anogenital distance of pups whose females received propofol on the fifteenth day of gestation. Based on these results, we concluded that administration of propofol in the beginning stages of gestation increases the number of abortions and promotes alterations in the physical development of pups whose mothers were anesthetized in the final stages of gestation.

Highlights

42% non-obstetrical surgeries are performed during the first trimester of pregnancy, 35% in the second and 23% in the third (Reitman & Flood, 2011; Mandim, Ruzi, Bernardes, & Teixeira, 2015)
The rate of post-implantational embryonic loss and the rate of embryonic resorption had a statistically significant increase in females in the group anesthetized on the fifth gestational day, DG 5 (Table 2)
The variations are usually reversible changes, characterized by not presenting risks to life and because they involve structural alterations of lesser functional significance. These results are in assent with those obtained by Mazze, Wilson, Rice and Baden (1985) who observed an increase in the frequencies of skeletal variation among the offspring of pregnant mice treated with small doses of the anesthetic isofluorane

Summary

Introduction

42% non-obstetrical surgeries are performed during the first trimester of pregnancy, 35% in the second and 23% in the third (Reitman & Flood, 2011; Mandim, Ruzi, Bernardes, & Teixeira, 2015). The incidence and types of surgeries performed in pregnant women was similar to that performed in young women who were not pregnant, and appendectomies were the most common (Van de Velde & De Buck, 2007). In utero exposure to anesthetic of laboratory animals decreased acquiring spatial memory (Palanisamy et al, 2011). These data suggest that fetal brain development can be permanently affected by maternal anesthesia

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