Abstract

<p><span lang="EN-IN">The aim of present study was to isolate, characeterise and evaluation anticoagulant properties of the isolated compound from aqueous extract of</span> <em>Cestrum nocturnum</em> using aPTT-Activated Partial Thromboplastin Time, PT- Prothrombin Time & TT-Thrombin Time as standard procedures.</p><p>From all the result it can be concluded that water extract of<span class="apple-converted-space"> </span><em>Cestrum nocturnum</em>plant was found to be best among all the extract under study and from the isolates of water extract of<span class="apple-converted-space"> </span><em>Cestrum nocturnum<span class="apple-converted-space"> </span></em>plant AE5 was found to be best activity (anti-platelet, Fibrinolytic and anti-coagulant). Further fractionation of water extract generated two isolates AE5a & AE6a and after their pharmacological activity they were found to be potent phytochemical constituents. From the structural elucidation study of AE5a & AE6a were identified as Rutin and quercetin respectively.</p><p>From this study it was concluded that the flavoinoidal compound i.e. Rutin and Quercetin were present in the<span class="apple-converted-space"> </span><em>Cestrum nocturnum<span class="apple-converted-space"> </span></em>plant and they both responsible for the anti-platelet, Fibrinolytic and anticoagulamt activity of plant.</p>

Highlights

  • Medicinal plants have been used as a source of medicine in all cultures during the last decades

  • The completion of the extraction was confirmed by evaporating a few drops of extract from the thimble on watch glass to observe that no residue remained after evaporation of the solvent

  • The effect on the in vitro study of activated partial thromboplastin time (aPTT), prothrombin time (PT) and thrombin time (TT) seconds of isolated fraction of (AE1 to AE10) aqueous extract of Cestrum nocturnum is presented in Table 4.The isolated fraction were evaluated by using two concentration i. e. 50 μM &100 μM. from the result which were obtained it can be say that the results were migrating around the previous result obtained with the concentration of 10mg/mL of the aqueous extract of the plant and PAGE | 496 |

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Summary

Introduction

Medicinal plants have been used as a source of medicine in all cultures during the last decades It is gradually becoming popular throughout the world [1]. Secondary metabolites of plants play an important role in medical care for a good percentage of world population and have been the source of inspiration for several major pharmaceutical drugs. DOI:10.5138/09750185.1971 present in plants have medicinal values which produce definite physiological actions in the body. These components are called phytochemicals, the most important of these bioactive groups being: alkaloids, steroids, terpenoids, flavonoids, tannins and phenolic compounds [5]. Panaxnoto ginseng and Panaxquinque folium are good sources of lead compounds for novel anti-platelet and anticoagulant therapeutics [12]. The source of innovative and powerful therapeutic agents for newer, safer and affordable medicines [15,16]

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