Year-end Sale % OFF 
Abstract
In this study, the anti-convulsant effect of Sinapis alba seed oil and its combination with sodium valproate was evaluated in Wistar albino rats using the lithium-pilocarpine Status Epilepticus (SE) model. The experimental groups included: Group I - normal control; Group II - disease control; Group III - Sinapis alba seed oil; Group IV - sodium valproate; Group V - Sinapis alba seed oil + ½ dose sodium valproate. Antioxidant markers and Brain-Derived Neurotrophic Factor (BDNF) levels were measured from the brain samples. The pathological changes were also determined using Cresyl violet staining. Sinapis alba oil did not prevent rats from developing status epilepticus but reduced the intensity and frequency of occurrence. Oil administration increased antioxidant levels and decreased lipid peroxide levels as well. The combination of oil and sodium valproate showed a synergistic effect in the status epilepticus model. The study results show that Sinapis alba can be used as an adjuvant in status epilepticus along with other antiepileptic drugs.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
