Abstract
Purpose: To evaluate the effect of Schisandrachinensis polysaccharides (SCPP11) on the growth of tuberculosis (TB) bacilli in a rat model.Methods: Tuberculosis (TB) was induced by administration of colonies of tubercle bacilli via the inhalation route. SCPP11 was administered at separate doses of 25, 50 and 100 mg/kg to different rat groups, p.o., for 4 weeks. Untreated rats served as TB control. At the end of treatment, assessments were made on the effect of SCPP11 on colony forming unit (CFU), cytokine levels, and population of immune cells present in lung tissue homogenates of the TB-infected rats.Results: The CFU of TB bacilli was significantly reduced in the lung tissues of SCPP11-treated group, when compared to untreated TB control group. Moreover, SCPP11 attenuated lung tissue levels of inflammatory cytokines, and significantly enhanced immunity, relative to the TB control group.Conclusion: These results indicate that SCPP11 ameliorates TB by suppressing the growth of tuberculosis bacilli.Keywords: Schisandra chinensis, Polysaccharides, Immune cells, Tuberculosis bacilli, Cytokines
Highlights
Tuberculosis (TB) is caused by tubercle bacilli infection, which causes the death of approximately 1.2 million people every year throughout the world [1]
Studies have revealed that Schisandra chinensis polysaccharides promote the secretion of inflammatory cytokines, leading to the activation of NK cells, macrophages and lymphocytes [12]
The present study was carried out to evaluate the effect of Schisandra chinensis polysaccharides on Mycobacterium tuberculosis infection in a rat model of TB
Summary
Tuberculosis (TB) is caused by tubercle bacilli infection, which causes the death of approximately 1.2 million people every year throughout the world [1]. Schisandra chinensis (Turcz.) Baillis traditionally used for medicinal purposes in China [8]. It is used for enhancing the secretion of body fluids, and as a kidney tonic, and for calming the mind [9]. Several pharmacologically active polysaccharides are present in Schisandra chinensis [11]. Studies have revealed that Schisandra chinensis polysaccharides promote the secretion of inflammatory cytokines, leading to the activation of NK cells, macrophages and lymphocytes [12]. The present study was carried out to evaluate the effect of Schisandra chinensis polysaccharides on Mycobacterium tuberculosis infection in a rat model of TB. The level of statistical significance was set at p < 0.05
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