<i>LINGO2</i> and Movement Disorder Predisposition: Results of a Meta-Analysis

Abstract

Previous reports on the pathogenesis of age-related movement disorders such as Parkinson’s disease (PD) and essential tremor (ET) have shown the potential implication of the LINGO1 (leucine-rich repeat and immunoglobulin domain-containing protein) gene. Although LINGO2 has a high-degree of homology with LINGO1, it is less characterized, and the role of LINGO2 in the development of PD/ET remains elusive. This meta-analysis was conducted to evaluate the role of LINGO2 in PD/ET pathogenesis. A literature search was conducted until 30 March 2020 in accordance to the PRISMA guidelines. The keywords “LINGO2”, “PD”, and “ET” were used in combination to obtain case-control studies evaluating LINGO2 gene polymorphism and PD/ET predisposition. A total of 4 studies were included, all of which complied with the Hardy-Weinberg Equilibrium. Analysis on the pooled odds ratio and CI of the studies were performed for five genetic models, including allelic (mutant type (M) vs. wild type (W)), dominant (MM+WM vs. WW), recessive (MM vs. WM+WW), homozygous (MM vs. WW), and heterozygous (WM vs. WW) models. No significant association was observed between the LINGO2 polymorphism with PD/ET, although subgroup analysis indicated that the recessive models of rs7033345 and rs10812774 are significantly associated with ET predisposition in the Asian population. Larger studies on this association is needed in the future to warrant our results.