Abstract
We prepared FA-targeted and 10-hydroxycamptothecin loaded chitosan nanoparticles (FA-HCPT-NPs) with a combination of emulsion-solvent evaporation and chemical crosslinking method. In vitro cytotoxicity test to the Human Cervix Carcinoma cells (HeLa) was evaluated by cell morphology and internalization observation. The specicity of the FA-HCPT-NPs targeting cancerous cells was demonstrated by comparative intracellular uptake of HCPT-NPs and commercial availible HCPT injection. Laser confocal scanning imaging proved that FA-HCPT-NPs could greatly enhance up-take by HeLa cells. The morphological changes of HeLa cells showed the FA-HCPT-NPs could inhibit HeLa cells more effectively than HCPT-NPs and HCPT. The results indicated that the novel FA-HCPT-NPs could be a potential drug delivery system for tumor cell-selective targeting therapy.
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