Abstract
Purpose : To prepare a novel dexpanthenol (DEX)-loaded nanofiber mats for wound healing. Methods : A novel bioactive wound dressing formulation with dexpanthenol was developed by electrospinning method. Poly (lactic-co-glycolic acid), poly (ethylene oxide) and poly (caprolactone) were used as polymers. Morphological features, swelling properties, in-vitro release behavior, and cell viability properties of the formulations were evaluated. Results : Morphological examination of mats confirmed successful formation of the fibers. Swelling of nanofiber mats results was 34.44 ± 1.05, 18.59 ± 2.11, 86.06 ± 3.25 and 44.62 ± 1.75 % for polycaprolactone (PCL), PCL + DEX, poly lactic-co-glycolic acid (PLGA) and PLGA + DEX, respectively, and occurred in a controlled manner. PLGA + DEX formulation has advantage over PCL + DEX and poly (ethylene oxide) (PEO) + DEX due to controlled in-vitro release of DEX. The highest cell viability was afforded by PLGA+DEX formulation. Conclusion : DEX-loaded PLGA nanofiber formulation may be useful as an alternative wound dressing due its suitable mechanical and biological properties. Keywords : Dexpanthenol, Electrospinning, Wound dressing, Polycaprolactone, Poly lactic-co-glycolic acid, Poly (ethylene oxide)
Highlights
Electrospining has been taken into consideration for many years by scientist; its application to pharmaceutical field has been delayed
Polyvinyl alcohol (PVA), PCL, PEO, poly lactic-co-glycolic acid (PLGA), gelatin, collagen, chitosan, Polyglycolic acid (PGA), fibrinogen and silk can be used for producing nanofiber mats
DEX loaded PLGA fibers significantly improved the cell viability compared to unloaded PLGA fiber coated slides (p < 0.05); while there was no significant increase in DEX loaded PCL and PEO fibers compared to unloaded PCL and PEO formulations (p > 0.05)
Summary
Electrospining has been taken into consideration for many years by scientist; its application to pharmaceutical field has been delayed. Wound healing is known as a natural body response when the skin is damaged [2]. Polyvinyl alcohol (PVA), PCL, PEO, PLGA, gelatin, collagen, chitosan, Polyglycolic acid (PGA), fibrinogen and silk can be used for producing nanofiber mats. PEO is water soluble and has a linear structure [7] It has been widely used for medical applications as electrospun nanofibers [8]. It is readily oxidized to pantothenic acid, a building block of of coenzyme A (CoA) [10] It has been reported by clinical observations that topically applied DEX is an aid in superficial wound healing with minimal risk of skin irritancy [11]. DEX-loaded PLGA, PEO and PCL nanofiber mats by electrospinning method for wound healing.
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