&lt;i&gt;Helicobacter pylori&lt;/i&gt; infection and atrophic gastritis

An Longdoh,Ia Ebule,Il Paloheimo

doi:10.4314/ahs.v13i1.15

<i>Helicobacter pylori</i> infection and atrophic gastritis

An Longdoh, Ia Ebule + Show 1 more

Open Access

https://doi.org/10.4314/ahs.v13i1.15

Copy DOI

Abstract

Helicobacter pylori-infection associated gastritis is known to be a significant risk factor of gastric cancer. Serum levels of Gastrin-17 and Pepsinogen1which are respectively biomarkers of gastric antral and corpus mucosal activity are well known parameters of atrophic gastritis. To determine the prevalence of Helicobacter pylori and atrophic gastritis amongst dyspeptic patients and to compare the production of PGI and G-17 in the various atrophic stages. A total of 139 dyspeptic patients aged 46.68±15.50 years [females 106 aged47.23±15.51years, males 33 aged 44.48±14.62] were included during the one year period, March 2008-april 2009 at the district hospital Tombel. The degree of atrophy was determined by the levels of serum pepsinogen1, and gastrin-17 and the presence of Helicobacter pylori antibodies detected by an enzyme immunoassay. The prevalence of Helicobacter pylori was 79.82% and that for atrophic gastritis was 6.6%. A decrease in mean serum levels of gastin-17 along with increasing antral atrophy was observed; the mean serum levels of pepsinogen1 were reduced during progression of corpus atrophy. A weak reverse correlation(r =-0.036) was found between Gastrin-17 and Helicobacter pylori antibodies.

Highlights

IntroductionThe inflammation of the mucosa of the stomach still remains a serious medical problem for many people world wide
Gastritis, the inflammation of the mucosa of the stomach still remains a serious medical problem for many people world wide. Complications such as peptic ulcer and gastric cancer will result from untreated gastritis[1]
Demographic factors containing the date of birth, April 2009]. 79.86% were Helicobacter positive in sex, ethnic group, marital status and employment serology (HpAbe>30EIU) and prevalence of states were administered to participants and all atrophic gastritis was 6.6%

Summary

Introduction

The inflammation of the mucosa of the stomach still remains a serious medical problem for many people world wide. Complications such as peptic ulcer and gastric cancer will result from untreated gastritis[1]. Serum levels of Gastrin-17 and Pepsinogen1which are respectively biomarkers of gastric antral and corpus mucosal activity are well known parameters of atrophic gastritis. The degree of atrophy was determined by the levels of serum pepsinogen[1], and gastrin-17 and the presence of Helicobacter pylori antibodies detected by an enzyme immunoassay.

Objectives

Methods

Results

Discussion

Conclusion