<i>Garcinia cambogia</i> ethanolic extract protects the liver from ciprofloxacin-induced hepatoxicity

Abstract

Objective: This study investigated the effects of the ethanolic extract of Garcinia cambogia on ciprofloxacin – induced hepatotoxicity. Method: Twenty (20) adult male Wistar rats were divided into four groups; Group A were given ciprofloxacin only (150 mg/kg b.w), Group B were given ciprofloxacin (150 mg/kg b.w) and extract (400 mg/kg b.w) simultaneously, Group C were given extract only (400 mg/kg b.w) and Group D served as control and received 1.5ml of distilled water as placebo. Serum and liver tissue were collected and processed for biochemical and histological studies respectively. Results: The result of this work showed significantly elevated levels of aspartate transaminase (ASP), alkaline phosphatase (ALP) and alanine transaminase (ALT) in ciprofloxacin-treated rats compared to the Garcinia cambogia -treated and control groups. The histological analysis also showed distortion of the lobular architecture and presence of inflammatory cells within the sinusoids and hepatocellular apoptosis in Group A. Conclusion: The results showed that Garcinia cambogia attenuates the toxic effects of ciprofloxacine on the liver. Keywords: hepatoxicity, lobular architecture, Garcinia cambogia , serum, enzyme markers