&lt;i&gt;COMT&lt;/i&gt; Val158Met (rs4680) polymorphism and vital exhaustion in an open 45–64-year-old population (international epidemiological WHO MONICA and HAPIEE programs)

V V Gafarov,I V Gagulin,V N Maksimov,E A Krymov,E A Gromova,D O Panov,A V Gafarova

doi:10.14412/2074-2711-2019-4-57-60

Abstract

Objective: to study the association of the polymorphic genotypes of rs4680 in the catechol-O-methyl transferase (COMT) gene with vital exhaustion (VE) in a 45–64-year-old population. Patients and methods. A representative sample of a 45–64-year-old population (781 men and 869 women) was surveyed within screening IV of the international Health, Alcohol and Psychological Factors in Eastern Europe (HAPIEE) program and the WHO MONICA-psychosocial program in 2003-2005. All the study participants filled out a VE scale of the WHO MONICA-psychosocial program. COMT Val158Met (rs4680) polymorphism was genotyped. Pearson' χ2 test was used to test the statistical significance of differences between these groups. The statistical significance level was taken to be p≤0.05 in all types of analysis. Results and discussion. Heterozygous G/A polymorphism in the COMT gene was most common in both the general population (48.6%) and men (44.4%) and women (51.5%). In the general population, the A/A genotype was more common in individuals with a high VE (HVE) level; in women and men, it was detected in 13.3 and 30.8% of cases, respectively. The G/G genotype prevailed in individuals with moderate VE in both the general population (31.1%) and women (29.7%) and men (33.3%). Conclusion. In the general population, the A/A genotype was found to be more common in individuals with HVE (18.6%), in women (13.3) and in men (30.8%).

Highlights

Гафаров В.В.1,2, Громова Е.А.1,2, Панов Д.О.1,2, Максимов В.Н.1, Гагулин И.В.1,2, Крымов Э.А.1,2, Гафарова А.В.1,2 1Научно-исследовательский институт терапии и профилактической медицины – филиал Федерального исследовательского центра «НИИ цитологии и генетики» Сибирского отделения Российской академии наук, Новосибирск, Россия; 2Межведомственная лаборатория эпидемиологии сердечно-сосудистых заболеваний, Новосибирск, Россия
All the study participants filled out a vital exhaustion (VE) scale of the WHO MONICA-psychosocial program
Heterozygous G/A polymorphism in the catechol-O-methyl transferase (COMT) gene was most common in both the general population (48.6%) and men (44.4%) and women (51.5%)

Summary

Introduction

Гафаров В.В.1,2, Громова Е.А.1,2, Панов Д.О.1,2, Максимов В.Н.1, Гагулин И.В.1,2, Крымов Э.А.1,2, Гафарова А.В.1,2 1Научно-исследовательский институт терапии и профилактической медицины – филиал Федерального исследовательского центра «НИИ цитологии и генетики» Сибирского отделения Российской академии наук, Новосибирск, Россия; 2Межведомственная лаборатория эпидемиологии сердечно-сосудистых заболеваний, Новосибирск, Россия. Как в общей популяции (48,6%), так и среди мужчин (44,4%) и женщин (51,5%), наиболее распространенным был гетерозиготный полиморфизм G/A гена COMT.

Objectives

Results

Conclusion