Abstract
The effect of aqueous-alcoholic tincture of Сalendula officinalis L. (Asteraceae) on tumor cells of different species and tissue origin was studied. Its potential as a radiosensitizer in combination with γ-radiation was determined. It has been established that C. officinalis tincture causes the death of tumor cells regardless of their p53 and p21 status. C. officinalis tincture has antioxidant properties, but for cells with active p21 it exhibits radiosensitizing rather than radioprotective properties. For cells lacking p21, C. officinalis tincture is a radioprotector, so the cell death is p21 mediated. A study of the radiosensitizing properties of C. officinalis was carried out on a mouse melanoma model in vivo. In combination with γ-radiation, it led to a significant inhibition of tumor growth (by 47%), as compared to irradiation only. The significant radiosensitizing effect and capability of overcoming the tumor cells resistance induced by p53 inactivation make C. officinalis tincture promising as an add-on to radiotherapy, allowing to reduce the effective radiation dose 1.7 times.
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