Abstract
Virus-like particles were found in the Shionogi carcinoma 115 (SC-115) cells. SC115 cells are known as an androgen-dependent mouse mammary tumor. Ultrastructural examinations of androgen-dependent growing tumor cells showed virus-like particles with outer diameters of about 83 nm, exclusively in the cisternae of the rough endoplasmic reticulum and the nuclear envelope. The particles were also observed in all of the mitotic cells examined. The number of particles in SC-115 cells increased with tumor growth after transplantation of cells into male mice. However, no virus-like particles were seen in the tumor cells transplanted into castrated male mice. A relationship is proposed between the appearance of viruslike particles and androgen-dependent oncogenesis of SC-115.
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