Abstract
A teratogen, N,N'-bis-(dichloroacetyl)-diamine,1,8,-octa methylene diamine (bisdiamine) induces endocardial cushion defects in the rat. We examined the effect of bisdiamine on the interaction between embryonic endocardium-derived cushion mesenchymal cells and extra-cellular matrix. Bisdiamine suspended in aqueous solution of gum tragacanth was orally administered to maternal rats at a dose of 200 mg/day on days 9 and 10 of gestation. Cushion mesenchymal cells from 13-day-old embryos were cultured on vitronectin, fibronectin, collagen type I with a serum-free medium, and the migration distance of cushion mesenchymal cells was measured
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