Abstract
In order to determine whether induction of intercellular adhesion molecule-1 (ICAM-1) mRNA by interferon-γ or tumor necrosis factor-a is a primary genetic response or requires a prior synthesis of other gene products, we examined the effects of the protein synthesis inhibitors, cycloheximide and puromycin, on the ICAM-1 mRNA induction in cell lines derived from human squamous cell carcinoma. Unexpectedly, treatment with either cycloheximide or puromycin alone led to a marked increase in the level of ICAM-1 mRNA. The mRNA induction by both protein synthesis inhibitors occurred in a dose-dependent manner
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