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Abstract
Rat pancreatic acini were isolated by collagenase digestion and exposed to cholecystokinin octapeptide (CCK-8) at concentrations of 0, 10 -10 and 10 -8 M. Secretion was monitored by measuring the release of amylase activity into the incubation medium that consisted of oxygenated HEPES-buffered Ringer's solution containing 2.5 mM Ca 2+ . The release of lactate dehydrogenase (LDH) into the incubation medium was measured to detect cell injury. The morphology of acinar cells was studied by light microscopy and scanning and transmission electron microscopy. A marked secretory response to stimulation with an optimal concentration of CCK-8 (10 -10 M) resulted in unaltered acinar cell morphology and in insignificantly increased LDH release as compared to non-stimulated controls
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