Abstract
Oxidative stress is an imbalance between reactive oxygen species and antioxidant capacity of action. Thus, research, alternative to mitigate the damaging effects of oxidative stress, improving the body´s antioxidant capacity, prevented the disease and its complicatons. The leaves and fruits of guava are rich in the antioxidants. This work aimed to study the effect of flour and ethanolic/acetone extracts leaves and fruits of guava on lipid oxidation in rats with hypercholesterolemic. The flour and extracts decreased leves of triglycerides and non – HDL cholesterol and increased in the HDL. Cholesterol levels decreased only leaves and fruits. The activity of GPx decreased in samples serum in all treatments and the SOD only the extracts were effective. There was no difference in levels the MDA in relation hypercholesterolemic control. For the samples of liver, there was no difference in activity SOD. In relation of activity GPx, only the flour was effective. There were differences in levels the MDA of the hypercholesterolemic animals treated with flour and extracts with the animals of the hypercholesterolemic control.
Highlights
In recent decades cardiovascular diseases began to be the main cause of mortality in the developed and in the developing countries
The excess cholesterol stimulates the production of reactive oxygen species (ROS), contributing to
Excess ROS leads to the alteration in the signaling and redox control processes and/or molecular harm, a condition known as oxidative stress (SEIFRIED et al, 2007)
Summary
In recent decades cardiovascular diseases began to be the main cause of mortality in the developed and in the developing countries. The excess cholesterol stimulates the production of reactive oxygen species (ROS), contributing to. Biological Sciences endothelial dysfunction, LDL modification and reduction of the antioxidant defense system, such as the decrease in the superoxide dismutase enzyme (SOD) and glutathione peroxidase activities (GPx) (LESTER et al, 2009). Those enzymes act together to inactivate ROS. A defense system that impedes or minimize those species in the organism is important to reduce cardiovascular disease risk development
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