Abstract
The central nervous system (CNS) effects of thyrotropin-releasing hormone (TRH) and of its analogue, (3R,6R)-6-methyl-5-oxo-3-thiomorpholinylcarbonyl-L-histidyl-L-prolinamide tetrahydrate (NS-3, CG-3703) on the CNS were compared in mice and rats. NS-3 and TRH increased the spontaneous locomotor activity, reversed reserpine-induced hypothermia, antagonized narcosis caused by pentobarbital Na and protected mice from loss of consciousness caused by head concussion
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