LSMO Nanoparticles Coated by Hyaluronic Acid for Magnetic Hyperthermia.

Yuanwei Chen,Xi Liu,Ying Wang,Tao Wang,Mai Lu,Jiangwei Cao

doi:10.1186/s11671-016-1756-3

Yuanwei Chen, Xi Liu + Show 4 more

Open Access

https://doi.org/10.1186/s11671-016-1756-3

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Abstract

Magnetic hyperthermia with the treating temperature range of 41–46 °C is an alternative therapy for cancer treatment. In this article, lanthanum strontium manganates (La1−xSrxMnO3, 0.25 ≤ × ≤ 0.35) magnetic nanoparticles coated by hyaluronic acid (HA) which possesses the ability of targeting tumor cells were prepared by a simple hydrothermal method combined with a high-energy ball milling technique. The crystal structure, morphology, magnetic properties of the HA-coated magnetic nanoparticles (MNPs), and their heating ability under alternating magnetic field were investigated. It was found the HA-coated La0.7Sr0.3MnO3, with particle diameter of ~100 nm, Curie temperature of 45 °C at a concentration 6 mg/ml, gave the optimal induction heating results. The heating temperature saturates at 45.7 °C, and the ESAR is 5.7 × 10−3 W/g · kHz · (kA/m2) which is much higher than other reported results.Electronic supplementary materialThe online version of this article (doi:10.1186/s11671-016-1756-3) contains supplementary material, which is available to authorized users.

Highlights

Magnetic hyperthermia is considered as an alternative therapy for cancer treatment since it has no side effect compared with traditional drugs or radiation treatment [1, 2]
All the XRD patterns correspond to the characteristic peaks of LSMO [11], except for the small peaks of La(OH)3 in (b) and (c)
The hyaluronic acid (HA)-coated La0.7Sr0.3MnO3 magnetic fluid with the saturation heating temperature of 45.7 °C and magnetic particle size of ~100 nm could satisfy the requirements of the mild hyperthermia temperature range (41–46 °C) and good cell compatibility for therapeutic application

Summary

Introduction

Magnetic hyperthermia is considered as an alternative therapy for cancer treatment since it has no side effect compared with traditional drugs or radiation treatment [1, 2]. The treating temperature of target tissue should be 41–46 °C to destroy the cancer cells while avoiding the harm on normal cells [3]. To prevent treating temperature to a higher value, a thermometry probe contacting with target tissue is always needed [4, 5]. This method is harmful when tumor is inside the body. For the sake of achieving this purpose, the series of La1−xSrxMnO3 (LSMO) compounds has attracted great interest in recent years [6,7,8]. The ferromagnetic–paramagnetic transition temperature Tc (Curie temperature) of LSMO compounds is from 10 to 97 °C with the variation of Sr content [9]. The Tc, MNPs lose the ability of generating caloric under

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