Abstract
Rats with a unilateral nigrostriatal lesion produced by infusion of 6-hydroxydopamine (6-OHDA) exhibited acute contralateral (apomorphine-like) rotation in response to systemic LSD administration. When re-introduced to the environment in which LSD had been administered weeks earlier, the animals exhibited a 2–3 min burst of coistralateral rotation. This behavior developed over a period of weeks and could be produced by a single LSD treatment. This latent, undrugged rotation is similar to that which we previously reported to result from one or more apomorphine treatments.
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