LS-SNP/PDB: annotated non-synonymous SNPs mapped to Protein Data Bank structures

Abstract

Abstract Summary: LS-SNP/PDB is a new WWW resource for genome-wide annotation of human non-synonymous (amino acid changing) SNPs. It serves high-quality protein graphics rendered with UCSF Chimera molecular visualization software. The system is kept up-to-date by an automated, high-throughput build pipeline that systematically maps human nsSNPs onto Protein Data Bank structures and annotates several biologically relevant features. Availability: LS-SNP/PDB is available at http://ls-snp.icm.jhu.edu/ls-snp-pdb and via links from protein data bank (PDB) biology and chemistry tabs, UCSC Genome Browser Gene Details and SNP Details pages and PharmGKB Gene Variants Downloads/Cross-References pages. Contact: karchin@jhu.edu Supplementary Information: Supplementary data are available at Bioinformatics online.