Abstract
Purpose: The signals responsible for homeostasis in the periodontal complex are unclear. The purpose of this study was to evaluate the role of Low-density lipoprotein receptor-related protein 5(LRP5) in this process by removing LRP5, and observing the effects of LRP5 depletion on cells of the periodontal structures. Material and Methods: The function of this LRP5 was evaluated by conditional elimination of the LRP5 gene using an Osteocalcin Cre driver. The OCN-Cre; mice were examined using micro-CT and histology, immunohistochemistry to evaluate the periodontal complex. Results: Elimination of LRP5 in the periodontal complex of OCN-Cre; mice results in a different expression of Fibromodulin in the periodontal ligament space. A decrease in osteoclastic activity was found in the periodontal ligament. Conclusion: Osteoclastic activities are decreased and expression of fibromodulin is decreased, which implies the involvement of LRP5 in homeostasis of the periodontal ligament.
Highlights
Low-density lipoprotein receptor-related protein 5 (LRP5) is known to be a key component in Wnt signaling pathway
Bone Volume Is Maintained in OCN-Cre; LRP5fl/fl Mice
Micro-CT examination of the craniofacial skeleton of OCN-Cre; LRP5fl fl mice revealed that similar bone volume of skeletal elements (Figure 1)
Summary
Low-density lipoprotein receptor-related protein 5 (LRP5) is known to be a key component in Wnt signaling pathway. Mutations in LRP5 cause alteration in bone mass. A deletion of LRP5 leads to a decrease in bone mass [1]. A gain in LRP5 causes an increase in bone mass [2] [3]. LRP5 is involved in disease related to bone. It has been known that homeostasis of bone mass is controlled by LRP5 through osteocytes [4] [5]. A controlling process of bone mass by LRP5 is not well estab-
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