Abstract
BackgroundGlioblastoma (GBM) is the most invasive primary intracranial tumor, and its effective treatment is one of the most daunting challenges in oncology. The blood–brain barrier (BBB) is the main obstacle that prevents the delivery of potentially active therapeutic compounds. In this study, a new type of pH-sensitive polymersomes has been designed for glioblastoma therapy to achieve a combination of radiotherapy and chemotherapy for U87-MG human glioblastoma xenografts in nude mice and significantly increased survival time.ResultsThe Au-DOX@PO-ANG has a good ability to cross the blood–brain barrier and target tumors. This delivery system has pH-sensitivity and the ability to respond to the tumor microenvironment. Gold nanoparticles and doxorubicin are designed as a complex drug. This type of complex drug improve the radiotherapy (RT) effect of glioblastoma. The mice treated with Au-DOX@PO-ANG NPs have a significant reduction in tumor volume.ConclusionIn summary, a new pH-sensitive drug delivery system was fabricated for the treatment of glioblastoma. The new BBB-traversing drug delivery system potentially represents a novel approach to improve the effects of the treatment of intracranial tumors and provides hope for glioblastoma treatment.
Highlights
Glioblastoma (GBM) is the most invasive primary intracranial tumor [1,2,3], and its effective treatment is one of the most daunting challenges in oncology [4]
AuNPs were synthesized by reducing the HAuCl4 solution with sodium citrate and modified with SH-PEG-NH2 to increase the stability and provide a group that will be coupled to DOX
In order to deepen our studies, the long-term effects of Au-DOX@PO-ANG used in vivo need continuous observation, and the optimal dose, treatment time and Conclusions In summary, a new targeted drug delivery system was fabricated for the treatment of glioblastoma
Summary
Glioblastoma (GBM) is the most invasive primary intracranial tumor [1,2,3], and its effective treatment is one of the most daunting challenges in oncology [4]. Current clinical chemotherapeutic treatments still show very limited therapeutic efficacy [5, 6].The blood–brain barrier (BBB) is the main obstacle that prevents the delivery of potentially active therapeutic compounds [7]. Limited tumor cell drug uptake and tumor resistance to chemotherapy have been observed. Due to the difference in acidity between solid tumors and surrounding normal tissues, pH-responsive polymersomes have been widely noticed and studied, and their great potential in more efficient delivery and rapid drug release in tumor cells has been described. The blood–brain barrier (BBB) is the main obstacle that prevents the delivery of potentially active therapeutic compounds. A new type of pH-sensitive polymersomes has been designed for glioblastoma therapy to achieve a combination of radiotherapy and chemotherapy for U87-MG human glioblastoma xenografts in nude mice and significantly increased survival time
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