LRP1 and Cerebral Amyloid Angiopathy

Abstract

Cerebral amyloid angiopathy (CAA), which causes intracerebral hemorrhage in the elderly population, is a major hallmark of Alzheimer’s disease. In CAA, amyloid-β (Aβ) deposition is mainly detected in the cortex and leptomeningeal arteries along the interstitial fluid drainage pathway. Failure to eliminate Aβ leads to accumulation of Aβ in the perivascular region and CAA. Several clearance routes of Aβ have been described, including elimination along the perivascular interstitial fluid drainage pathway, elimination through the blood–brain barrier and uptake and degradation by glia and neurons. All of these routes express the low-density lipoprotein receptor-related protein (LRP)1, which plays a critical role in Aβ clearance. Consequently, an impairment of Aβ clearance through LRP1 likely contributes to CAA pathogenesis. This review summarizes what is known about LRP1 and CAA as well as providing insights into the possible roles of LRP1 in Aβ clearance.