Abstract
Mutation or deletion of lipopolysaccharide responsive beige-like anchor (LRBA) gene causes common variable immunodeficiency, autoimmunity and chronic inflammation. However, the underlying molecular mechanism by which this occurs is unknown. LRBA is similar in structure to the lysosomal trafficking regulator gene. Therefore, it is hypothesized that LRBA may function as a regulator of vesicle trafficking. Its subcellular localization may help to decipher its function.
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