Abstract
The absence of lipopolysaccharide-responsive beige-like anchor (LRBA) gene causes common variable immunodeficiency (CVID), autoimmunity and chronic inflammation. It is the only CVID gene that regulates vesicle trafficking and signal transduction, required for the regulation and function of many immune molecules. It is hypothesized that LRBA deficiency causes these medical conditions by deregulating NFkB-mediated multiple immune effectors critical for B cell activation.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
