Abstract
AbstractA cascade organocatalysis is reported for the nucleophilic and electrophilic dual activation taking place in the reaction of methyl ketones or active methylene compounds with DMF‐DMA (N,N‐dimethylformamide dimethyl acetal). L‐Proline serves as an efficient organocatalyst in the covalent and noncovalent synchronous mode for the ambiphilic activation of various aryl, heteroaryl, and styryl methyl ketones, cyclic ketones, and 1,3‐diketones with DMF‐DMA to achieve the convenient syntheses of the versatile synthons (2E)‐1‐aryl/heteroaryl/styryl‐3‐(dimethylamino)‐2‐propen‐1‐ones, (E)‐α‐[(dimethylamino)formylidene]cycloalkanones, and (E)‐2‐(dimethylamino)formylidene‐1,3‐diketones in high yields under solvent‐free conditions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
