Abstract
Macrophage may play an important role in the atherogenic process because they appear to be precursors of some arterial wall foam cells. Recently, it has been reported that human peripheral monocytes in culture synthesize and secrete lipoprotein lipase (LPL). Consequently, it is possible that LPL secretion by human monocytes is related to atherogenesis. As shown below, guinea pig alveolar macrophages in culture synthesize and secrete LPL. Therefore we investigated the effect of lipoprotein on LPL activity of guinea pig alveolar macrophages.Alveolar macrophages were cultured for 2 days with either RPMI-1640 medium containing 10% lipoprotein deficient serum (LPDS) or that medium with the addition of VLDL, LDL, and HDL respectively in the concentration of 300μg protein/ml.When VLDL was added to LPDS after one day, LPL activity was significantly reduced to 48.3 within 2 days of exposure when compared with LPDS controls (p<0.02).We believe there is a possible explanation for this phenomenon, LPL activity may be inhibited by apoprotein C-III of VLDL.
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