Abstract
The aim of this study was to evaluate the changes in lipid and lipoprotein concentrations in postmenopausal women after 6 months of treatment with diosgenin as hormone replacement therapy. Forty-nine postmenopausal women attending the menopause unit at the Dr. Urquinaona central hospital who were treated with diosgenin were selected. Serum concentrations of cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were measured. Cholesterol and triglyceride concentrations rose after 6 months of treatment with diosgenin compared with initial values, but these increases were not statistically significant (p=ns). When LDL-C and HDL-C concentrations were analyzed, no statistically significant differences were found in plasma concentrations after 6 months of treatment compared with initial concentrations (p=ns). We conclude that diosgenin produces no significant modifications in mean lipid and lipoprotein values after 6 months of treatment in postmenopausal women administered this drug as hormone replacement therapy.
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