Abstract
Summary The effects of low-intensity laser (LIL) irradiation on the grading of the level of lens opacity (i), and on the level of lipid peroxidation products and activities of antioxidant enzymes in lens (ii) during experimental Diquat-induced Cataract in rabbit eyes were studied. At the end of 10 th week the lens of Diquat-treated animals opacitated to 4–5 grade. Subsequent treatment of the lens by low-intensity He-Na laser does not alter significantly the level of opacity (4–5 grade). It was observed that experimental model of Cataract lead to significant increase of lipid peroxidation products (conjugated dienes, malondialdehyde, fluorescent lipofuscine-like products) as well as to significant changes in antioxidant enzyme activities (increase of SOD-activity and decrease of Catalase-activity). Treatment of Diquat-modified lens by low-intensity He-Na laser resulted to a slight decrease of SOD-activity and does not affect additionally Catalase-activity. Summarizing, the results demonstrated that LIL-irradiation has not a protective effect on the cataractogenesis and oxidative stress, induced by Diquat in rabbit eyes. It is supposed that the effect ofLIL-irradiation on the experimental Cataract depends on the dose applied, prolongation of laser treatment and lens structure.
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