Abstract
Plasma and liver contents of malonic aldehyde are studied one day after administration of bromobenzene to mice pretreated with a polymeric form of zinc-metallothionein from rat liver. It is found that zinc-metallothionein injected in a dose of 1–4 mg/kg 5–10 min prior to injection of bromobenzene (2 g/kg, about 56% of LD50) markedly lowers the malonic dialdehyde level and active toxicity of this xenobiotic. Administration of a mixture modeling Zn-metallothionein (albumin, cysteine, and zinc) in a dose of 4 mg/kg has no appreciable effect on the malonic dialdehyde level raised after bromobenzene injection, and does not change its LD50. It is concluded that the protective effect of exogenous zinc-metallothionein is due to its antioxidant activity, which allows for normalization of lipid peroxidation.
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