Abstract
AbstractThe sensitivity of the heart to the negative chronotropic effect of acetylcholine (ACh) was measured in vivo from denervated hearts of the rat and frog before and after they were acclimated to cold. In the frog the possible seasonal changes in sensitivity were also observed. In the rat, cold acclimation lowered the sensitivity to ACh. This change was significant already at 3 days after cold exposure. Cold acclimation lowered the sensitivity to ACh also in the frog, but only during the winter. On the other hand, summer frogs were much niore sensitive to ACh than winter frogs. It was concluded that it is the increased parasympathetic activity in the cold‐acclimated rat and in the winter frog which results in the lowering of sensitivity to ACh.
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