Abstract
In addition to testosterone (T), the emerging role of sex hormone-binding globulin (SHBG) in pathogenesis of metabolic syndrome (MetS) has been noted recently. However, reports of associations with serum adipocytokine levels are still limited. Therefore, we conducted this study to evaluate whether serum T and SHBG levels are independent predictors for the risk of MetS that are associated with adiponectin and leptin levels in 614 Taiwanese men over 40 years old collected from a free health screening. Subjects in the lowest quartile of TT and SHBG levels are exposed to a 1.58 and 3.22 times risk of developing MetS, as compared to those in the highest quartile of TT and SHBG levels. However, SHBG retains its significance independent of TT as a MetS risk predictor, but not vice versa. In addition, SHBG was significantly correlated with both adiponectin and leptin levels even after adjusting for TT levels. In conclusion, SHBG served as a major predictor for the risk of MetS and was correlated with serum adiponectin and leptin levels that are independent of T. Further studies are needed to elucidate the true role of SHBG in the pathogenesis of MetS and possible mechanisms associated with serum adiponectin and leptin levels.
Highlights
Metabolic syndrome (MetS) is a collection of cardio-metabolic risk factors, including obesity, insulin resistance, hypertension, and dyslipidemia, appearing to affect approximately 10–40% of adult populations worldwide[1]
Many studies have investigated the relationships of serum T and sex hormone-binding globulin (SHBG) levels with the risk of MetS in men, only a few have focused on their relationships with serum adipocytokines, especially adiponectin and leptin levels
We conducted this study to evaluate whether serum T and SHBG levels are independent predictors for the risk of MetS that are associated with adiponectin and leptin levels in a large sample of middleto old-aged Taiwanese men
Summary
Metabolic syndrome (MetS) is a collection of cardio-metabolic risk factors, including obesity, insulin resistance, hypertension, and dyslipidemia, appearing to affect approximately 10–40% of adult populations worldwide[1] It has become a major public health concern in the twenty-first century due to its rapidly increasing prevalence in recent years and its utility as a predictor for the risk of type 2 diabetes mellitus (DM) and cardiovascular disease[2, 3]. Testosterone (T) is the principal sex hormone in men with both androgenic and anabolic effects that decline gradually, especially after the age of 409 It consists of three components, including T bound to sex hormone‐binding globulin (SHBG), T bound to albumin, and free testosterone (FT)[10, 11]. We conducted this study to evaluate whether serum T and SHBG levels are independent predictors for the risk of MetS that are associated with adiponectin and leptin levels in a large sample of middleto old-aged Taiwanese men
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