Abstract
Irisin as an exercise-induced myokine was proposed to improve bone health. This study investigated the role of serum irisin (s-irisin) in patients with osteoporosis (OP) through correlating to most biological bone markers and oxidative stress. A cross-sectional study recruited an eligible 175 postmenopausal women at Al-Hussien Teaching Hospital, Iraq. They were scanned by DEXA and stratified into two groups based on T-score; the first 95 patients as control group (GI) with -1 ≤ T-score and the second 80 patients as cases group (GII) with T-score ≤ -2.5. Demographic criteria were age, bone mineral density (BMD, g/cm2) and T-score. Serum irisin, total serum calcium (s-calcium), serum inorganic phosphate (s-phosphate), serum alkaline phosphatase (s-ALP), serum 25 [OH] vitamin D, the serum parathyroid hormone (s-PTH), serum Carboxy terminal collagen crosslinks (CTx), serum procollagen type I C-termidnal peptide (s-PICP), serum malondialdehyde (s-MDA) and serum superoxide dismutase (s-SOD) were collected from blood samples. Serum irisin were 31.84 ± 2.65 vs. 20.88 ± 2.71 ng/mL for control and trial groups, respectively. Lower levels of BMD, T-score, 25 [OH] vitamin D, and s-irisin along with a higher serum levels of PTH, CTx, PICP, MDA and SOD were observed in patients with osteoporosis. All parameters were statistically meaningful upon correlation (p< 0.0001), except age and s-calcium (p= 0.0088 and p= 0.187, respectively). The results showed that, a significantly lower serum irisin levels among osteoporosis women, was intimately correlated to most bone turnover markers and it can be considered as encouraging results for clinical application in prediction and treatment of osteoporosis.
Highlights
Osteoporosis (OP) is characterized structurally by bone mineral density (BMD) T-score −2.5 or less
S-CTx, serum procollagen type I C-termidnal peptide (s-PICP), serum 25 [OH] vitamin D, and serum parathyroid hormone (s-PTH), were measured using the enzyme-linked immunosorbent assay (ELISA) kit provided by Demeditec diagnostic testing GmbH Germany
A significant positive correlation was reached between irisin versus the BMD, s-phosphate, serum 25 [OH] vitamin D, and s-PICP in the GI and GII groups
Summary
Osteoporosis (OP) is characterized structurally by bone mineral density (BMD) T-score −2.5 or less. Menopause is a major etiological factor for OP; a daunting period when females are most vulnerable to climate change and hormone degradation [1,2,3]. BMD assessed with dualenergy X-ray absorptiometry (DXA) rigorously predicts substantial fractures, especially those involving the hip. Predictions strengthened when BMD is paired with additional diagnostic risk factors in predictive modules [4,5]. Numerous risk prediction methods have been suggested, both radiological and biological modules, aiming for the detection of individuals at high risk of fracture that are mostly like to get the maximum benefit from treatment [6]. Dynamic changes in bone metabolism especially turn-over markers may be best estimated by assessing
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
