Lower risk of multi-system inflammatory syndrome in children (MIS-C) with the omicron variant

Abstract

Multi-system inflammatory syndrome in children (MIS-C), also known as pediatric inflammatory multi-system syndrome temporally associated with SARS-CoV-2 (PIMS-TS), is an infrequent but severe post-infectious complication of COVID-19.1 The Paediatric Active Enhanced Disease Surveillance (PAEDS) network (www.paeds.org.au)2 initiated sentinel surveillance for MIS-C in May 2020. PAEDS used a case definition for MIS-C modified from the WHO definition (supplementary methods). PAEDS concurrently undertook surveillance for hospitalized COVID-19 and Kawasaki disease.