Lower Likelihood of Having Moderate-to-severe Lower Urinary Tract Symptoms in Middle-aged Healthy Korean Men With Metabolic Syndrome

Abstract

To investigate the impact of metabolic syndrome (MS) on lower urinary tract symptoms (LUTS) in middle-aged men. A total of 4256 ostensibly healthy native Korean men aged between 40 and 65 years who voluntarily underwent medical checkup were enrolled. Participants' demographics were collected including International Prostate Symptom Score, various metabolic risk factors, and prostate volume (PV). All participants were stratified into 2 groups based on the presence or absence of MS. The PV was used for subgroup analysis. Data from 4076 men were retrospectively analyzed. The mean age was 52.2 ± 7.4 years and 18.5% of patients were included in the MS group. The MS group had lower frequency score (P <.01) compared with the non-MS group. In the larger PV group (≥ 28 mL), the age-adjusted odds ratio (OR) for having moderate-to-severe LUTS was significantly lower in subjects with MS having 3 metabolic risk factors (hypertension and hypertriglyceridemia included; OR, 0.666; P <.01) and in subjects with MS having 4 or 5 risk factors (OR, 0.612; P <.05) compared with the non-MS group. We confirmed that MS with increasing number of MS risk factors (especially hypertension and hypertriglyceridemia) had favorable effects on the likelihood of having moderate-to-severe LUTS in middle-aged men with larger PV.