Abstract

Take home message Aim for a systolic blood pressure lower than the current recommended goal of 140 mm Hg. Optimum systolic blood pressure should be targeted to 120–130 mm Hg, especially in nondiabetic hypertensive patients with significant risk factors. Advantages of aggressive treatment to levels <120 mm Hg are still unclear. Lifestyle modifications rather than initiation of antihypertensive drug treatment should be advocated in individuals with high-normal blood pressure and no history of cardiovascular events.

Highlights

  • The Systolic Blood Pressure Intervention Trial (SPRINT)[1] has had a major impact in the field of hypertension and cardiovascular medicine— has it clearly shown increased cardiovascular benefit when systolic blood pressure is targeted to lower levels (

  • E-mail: rhian.touyz@glasgow.ac.uk practically is, at what threshold should treatment be initiated and what is the optimal systolic blood pressure that should be strived for to prevent or reduce hypertensionassociated adverse consequences? The fear of reducing blood pressure too low such that patients are at risk of stroke, transient ischemic attack, or renal ischemia is as important as the concerns of not lowering blood pressure enough to prevent the risk of stroke, heart failure, or coronary events in hypertensive patients

  • The SPRINT results have provided robust data demonstrating that aiming for systolic blood pressure of

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Summary

Introduction

The Systolic Blood Pressure Intervention Trial (SPRINT)[1] has had a major impact in the field of hypertension and cardiovascular medicine— has it clearly shown increased cardiovascular benefit when systolic blood pressure is targeted to lower levels (

Results
Conclusion

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