Abstract

Studies have shown marked variability in the pharmacokinetics of daptomycin in acutely ill patients. Although use of 6 mg/kg daily is suggested for treating infections caused by gram-positive organisms, high-dose (10 mg/kg daily) daptomycin is recommended for persistent methicillin-resistant Staphylococcus aureus bacteremia not responsive to vancomycin. In a recent open-label, prospective study …

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