Abstract
AimsTo investigate the predictive value of baseline serum triglyceride (TG) levels for improvements of metabolism after laparoscopic sleeve gastrectomy (LSG).Methods112 obese patients [body mass index (BMI) ≥ 35 kg/m2] underwent LSG and with complete information of anthropometric and metabolic parameters were divided into normal TG group (group A) and high TG group (group B), while group A had TG levels ≤ 1.7 mmol/L, and group B had TG levels > 1.7 mmol/L. The post-operative changes (Δ) in metabolic parameters between the two groups were compared.ResultsIn the whole cohort, the metabolic parameters were significantly improved at 6 months after LSG. BMI and waist circumference (WC) decreased significantly in the two groups. The ΔBMI among group A and group B were 11.42±3.23 vs 9.13±2.77 kg/m2 (p<0.001), respectively. ΔBMI was positively correlated with ΔWC (r=0.696, p<0.001), Δfasting insulin level (r=0.440, p=0.002), Δfasting serum C peptide level (r=0.453, p=0.002), and Δhomeostasis model assessment insulin resistance index (r=0.418, p=0.004) in group A. Compared with group B, group A had a significantly higher odds ratio (OR) of 2.83 (95% confidence interval [CI]1.25–6.38, p=0.012)and 2.73 (95% CI 1.11–6.72, p=0.029) for ΔBMI and ΔWC after adjustment for age and gender, respectively.ConclusionsObese patients with baseline TG levels under 1.7 mmol/L had greater loss of weight at six months follow-up later LSG. This finding suggests that baseline TG level may have a predictive value for weight loss, at least in the short-term follow-up.
Highlights
Obesity is a major public health concern globally [1]
The BMI, neck circumference (NC), waist circumference (WC), WHR, and levels of FPG, fasting insulin (FINS), fasting serum C peptide (FCP), HbA1c, and HomA-IR were significantly improved after Laparoscopic sleeve gastrectomy (LSG) in both groups (p
The present study demonstrated that the levels of the blood glucose and lipids in both group A and B were significantly improved at 6 months after LSG, but it is worth highlighting that patients with a normal TG had greater improvements in BMI and WC
Summary
Obesity is a major public health concern globally [1]. Based on adipose tissue distribution in the body (upper body and lower body), obesity can be divided into abdominal obesity and gluteofemoral obesity [2]. Abdominal obesity is one of the symptoms of metabolic syndrome (MS), and is a risk factor for cardiovascular disease (CVD) and diabetes mellitus [3, 4]. Healthcare professionals have employed several treatment methods to improve weight loss management. Metabolic surgery has become an internationally recognized method for long-term and effective weight control and for improvement in metabolic disorders [5]. Laparoscopic sleeve gastrectomy (LSG) is one of the most commonly used methods and has been employed by clinicians globally for many years [6,7,8,9]. Triglyceride (TG) is an important clinical feature of MS and associated with metabolic abnormalities in nonalcoholic fatty liver disease and abdominal obesity [10, 11]. The prognostic value of TG in obese patients treated with LSG remains unknown
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