Abstract
Background: Aspirin use has been associated with improved survival rates in various cancers. However, it remains unclear if aspirin confers a survival benefit on patients with nasopharyngeal carcinoma (NPC). The aim of this study was to assess the associations between aspirin use and survival in different stages of NPC. Methods: This is a 10-year retrospective cohort study of NPC patients. A total of 565 NPC patients were recruited after we performed a 1:4 propensity score match between aspirin users and non–users. Cox regression models with adjusted covariates were employed to evaluate factors that influence the survival rate of NPC patients. Results: The Kaplan-Meier analysis revealed that the overall survival (p < 0.0001) and disease-specific survival (p < 0.0001) rates of 180-day aspirin users increased. Increased survival rates were also observed in 180-day aspirin users with Stages III and IV, T, N1 and 2, and N3 categories. Cox regression models indicated that factors, including aspirin use (univariate: HR = 0.28, 95% CI = 0.14–0.55, p < 0.001; multivariate: HR = 0.23, 95% CI = 0.12–0.46, p < 0.001), were independent prognostic factors for survival. Conclusions: Aspirin use for more than 180 days is associated with an increased survival rate and is a positive independent prognostic factor in NPC.
Highlights
Nasopharyngeal carcinoma (NPC) is a malignant tumor in the head and neck areas
The cohort was comprised of a total of 2666 patients who were diagnosed with nasopharyngeal carcinoma (NPC) in Chang
Among the 2666 NPC patients, a total of 463 patients were not recruited after applying the exclusion criteria
Summary
Nasopharyngeal carcinoma (NPC) is a malignant tumor in the head and neck areas. Unlike other head and neck cancers, NPC is characterized by increased invasiveness and metastasis [1,2,3,4].Clinical presentation of NPC is highly varied and often results in delayed or missed diagnosis due to its anatomical position [5,6]. Nasopharyngeal carcinoma (NPC) is a malignant tumor in the head and neck areas. Unlike other head and neck cancers, NPC is characterized by increased invasiveness and metastasis [1,2,3,4]. NPC is rare in most parts of the world, it has a higher regional incidence in Asia than in Western countries [2,8,9]. Aspirin use has been associated with improved survival rates in various cancers. It remains unclear if aspirin confers a survival benefit on patients with nasopharyngeal carcinoma (NPC). The aim of this study was to assess the associations between aspirin use and survival in different stages of NPC. Results: The Kaplan-Meier analysis revealed that the overall survival (p < 0.0001) and disease-specific survival (p < 0.0001) rates of
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