Abstract
At low doses, substituted benzamides such as sulpiride, levosulpiride, and amisulpride preferentially block the higher affinity dopamine autoreceptors that are located on the presynaptic neuron1,2; this results in increased release of dopamine,1,2 an effect that is useful for the treatment of depression,3 somatoform disorders,4 and negative symptoms of schizophrenia.3 At high doses, these drugs also block the lower affinity dopamine postsynaptic receptors,1,2 effectively ameliorating positive symptoms of schizophrenia.5 Given that dopamine inhibits the release of prolactin, would low doses of these drugs lower serum prolactin and high doses lead to hyperprolactinemia?
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
