Low-density lipoprotein cholesterol target attainment in post-acute coronary syndrome patients: About a prospective study

Abstract

Background and Aims : - During acute coronary syndrome(ACS), lowering LDLc with high-dose statins reduces the risk of recurrent cardiovascular events, which is why the 2019 ESC recommendations advocate lowering LDLc to less than <0.55g/l and reducing the initial level by 50%. - In our country, little data is available on LDLc levels. through this study, never realized in Algeria before, We aimed to assess LDLc target attainment in post-ACS patients according to the latest recommendations.Methods: - This observational study was realized at the cardiology department of Hussein Dey hospital, from September 2020 to January 2021, 146 patients hospitalized for ACS were included, 80,8% were male. - lipid assessment was performed after admission and 08 weeks after the start of statin. All patients received « Atorvastatin 80mg » as a lipid-lowering treatment(LLT). - Statistical analyses were conducted using SPSS, factors associated with failure to achieve LDLc target were identified using multivariate logistic regression.View Large Image Figure ViewerDownload Hi-res image Download (PPT)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Conclusions: - Despite the patient's adherence to treatment and the use of high-intensity statin, achieving an LDL-C target lower than 0.55 g/L is difficult. - The implementation of ezetimibe and PCSK9 inhibitors now seems unavoidable to help increase the achievement of the LDL-C target recommended. Background and Aims : - During acute coronary syndrome(ACS), lowering LDLc with high-dose statins reduces the risk of recurrent cardiovascular events, which is why the 2019 ESC recommendations advocate lowering LDLc to less than <0.55g/l and reducing the initial level by 50%. - In our country, little data is available on LDLc levels. through this study, never realized in Algeria before, We aimed to assess LDLc target attainment in post-ACS patients according to the latest recommendations. Methods: - This observational study was realized at the cardiology department of Hussein Dey hospital, from September 2020 to January 2021, 146 patients hospitalized for ACS were included, 80,8% were male. - lipid assessment was performed after admission and 08 weeks after the start of statin. All patients received « Atorvastatin 80mg » as a lipid-lowering treatment(LLT). - Statistical analyses were conducted using SPSS, factors associated with failure to achieve LDLc target were identified using multivariate logistic regression. Conclusions: - Despite the patient's adherence to treatment and the use of high-intensity statin, achieving an LDL-C target lower than 0.55 g/L is difficult. - The implementation of ezetimibe and PCSK9 inhibitors now seems unavoidable to help increase the achievement of the LDL-C target recommended.